Mandrixa commercial strategy consultancyMANDRIXADiscuss a decision

Commercial strategy consulting · CROs · CDMOs · life-science services

Growth is rarely lost in the market.

Commercial strategy consulting for CROs, CDMOs and specialist life-science service companies.

Mandrixa identifies where revenue, margin and commercial opportunity are lost across pricing, positioning, pipeline, scope, delivery, partnerships and buyer decision-making. Then it changes the commercial rule that caused the loss.

Margin erosionBuyer uncertaintyPartner leakageCapacity misallocation
Alex RickmanCommercial decision architect / Fractional CCO
Alex Rickman, founder of Mandrixa
Evidence · Decisions · Movement

Commercial strategy for specialist life-science services

Where commercial performance breaks down.

Across CROs, CDMOs and life-science service companies, the visible problem is often sales. The economic constraint is usually pricing, positioning, pipeline quality, scope, buyer evidence, partnerships or capacity.

01

The work is winning. The margin is disappearing.

Pricing · scope · change · cash+
Mandrixa response

Margin Genome™

  • Reconstruct quoted versus realised contribution
  • Separate strategic investment from preventable leakage
  • Install price, scope and change-control decision rules
What changes

A deal-level erosion map and the commercial rules that stop the next project repeating it.

02

Buyers like the science. The decision still stalls.

Buyer truth · procurement · proof+
Mandrixa response

Buyer Reality Exchange™

  • Neutral interviews with buyers, lost deals and procurement
  • Internal belief versus external decision-weight analysis
  • Proof, packaging and willingness-to-pay corridors
What changes

Independent evidence of what changes the decision — and what merely earns polite interest.

03

Partnerships multiply. Incremental revenue does not.

Referrals · co-delivery · client control+
Mandrixa response

Ecosystem Yield & Control™

  • Partner-attributed gross-profit reconstruction
  • Influence, incrementality and servicing-cost tests
  • Customer, data, pricing and relationship-control map
What changes

A defensible decision to invest, renegotiate, repair or exit each material relationship.

04

The pipeline is full. The wrong work gets the capacity.

Activation · technical fit · cash velocity+
Mandrixa response

Capacity-to-Cash Conversion™

  • Separate award probability from technical activation
  • Compare contribution per scarce scientific unit
  • Set reservation, expiry and displacement rules
What changes

Capacity allocated to the work most likely to become contribution and cash — not the largest headline deal.

05

The symptoms are visible. The commercial constraint is not.

Position · offer · pipeline · economics+
Mandrixa response

Two-Week Commercial Decision Diagnostic

  • Read the evidence across six commercial dimensions
  • Rank the constraint behind the visible symptoms
  • Convert diagnosis into an owned 90-day decision plan
What changes

One executive-grade view of what is actually blocking growth — before money is spent on the wrong remedy.

06

The decision is made. It still does not survive execution.

Ownership · governance · cross-functional friction+
Mandrixa response

Commercial Decision Mandate

  • Executive decision rights and operating cadence
  • Complex-deal and commercial-exception governance
  • Board-ready evidence, ownership and movement
What changes

A senior commercial decision layer that remains accountable until the decision changes behaviour.

Proprietary CRO and CDMO commercial strategy frameworks

Built for evidence your own team cannot grade neutrally.

Each system combines independent evidence, cross-functional challenge and a rule your executive team can continue to use.

01

Margin Genome™

  • Mandrixa’s commercial erosion diagnostic identifies where margin is lost between opportunity, scope, delivery, change control and collection.
  • Deal-level erosion ledger
  • Service-line margin corridors
  • Scope and change trigger library
  • Procurement give / get rules
02

Buyer Reality Exchange™

  • Independent buyer and procurement evidence shows why scientific interest does not become a commercial decision.
  • Buyer decision-system map
  • Truth Gap heatmap
  • No-decision and procurement friction
  • Minimum-proof and packaging decision
03

Ecosystem Yield & Control™

  • A partner-economics system separates genuinely incremental revenue from servicing cost, influence and loss of customer control.
  • Partner yield / control matrix
  • Incrementality and attribution ledger
  • Incentive and fee waterfall
  • Invest / renegotiate / repair / exit rules
04

Capacity-to-Cash Conversion™

  • A CRO/CDMO capacity-allocation system ranks work by activation probability, contribution and cash realisation.
  • Contribution per scarce unit
  • Award versus activation risk
  • Capacity displacement decisions
  • Reservation and expiry governance

The Mandrixa method

Do not improve the symptom. Change the decision producing it.

01 / Frame

Name the executive decision, its owner and the evidence that would change it.

02 / Reconstruct

Rebuild what actually happened across commercial, finance, delivery, quality and the market.

03 / Decide

Make the trade-off explicit, confidence-graded and owned at executive level.

04 / Govern

Install the rule, decision artefact and review cadence that keeps it moving.

The operating standard

01One material decision per mandate
A–CConfidence graded, never hidden
90dNamed owner and review horizon
0Generic GTM theatre

Founder-led commercial decision practice

Independent enough to challenge. Experienced enough to decide.

Mandrixa is a commercial strategy consultancy for CROs, CDMOs and specialist life-science service companies. It is led by Alex Rickman, a life-sciences commercial leader experienced in pricing architecture, complex deals, recurring-revenue models and partnership economics.

The work sits where commercial intent collides with procurement, scientific delivery, quality, finance and executive judgement. It is not outsourced lead generation, generic marketing or RevOps.

View Alex on LinkedIn →

Commercial strategy answers

Questions CRO and CDMO leaders ask when growth stops converting.

Direct answers to the commercial problems that are too often treated as sales problems.

What does a CRO or CDMO commercial strategy consultant do?

An independent commercial strategy consultant identifies why scientific capability and sales activity are not translating into sufficient revenue, margin or market share. The work typically covers positioning, pricing, pipeline quality, buyer behaviour, service architecture and commercial decision-making.

What is commercial leakage?

Commercial leakage is revenue or margin a company could reasonably capture but loses through weak pricing, positioning, qualification, contracting, scope control, delivery handoffs, partnerships or account management.

Does a CRO need more business development or better commercial strategy?

More business development helps only when the proposition, target market, pricing and conversion system are already sound. If qualified opportunities stall or low-quality pipeline absorbs capacity, adding sellers can amplify the wrong commercial model.

How can a CDMO improve project margins?

A CDMO improves margin by tracing quoted contribution through scope, technical transfer, change control, delivery and collection, then installing explicit rules for exceptions, reservations, rework and procurement concessions.

When should a CRO or CDMO use a fractional CCO?

A fractional CCO is useful when the company faces material pricing, positioning, pipeline, partnership or capacity decisions but does not yet need, or cannot justify, a permanent full-time commercial executive.

Bring the decision, not a consultancy brief

Which commercial decision is being made with only half the evidence?

Discuss a decision
Mandrixa commercial strategy consultancyMANDRIXA

Commercial strategy consulting for CROs, CDMOs and specialist life-science service companies.